hnRNPC regulates cancer-specific alternative cleavage and polyadenylation profiles
نویسندگان
چکیده
منابع مشابه
Transcriptional activity regulates alternative cleavage and polyadenylation
Genes containing multiple pre-mRNA cleavage and polyadenylation sites, or polyA sites, express mRNA isoforms with variable 3' untranslated regions (UTRs). By systematic analysis of human and mouse transcriptomes, we found that short 3'UTR isoforms are relatively more abundant when genes are highly expressed whereas long 3'UTR isoforms are relatively more abundant when genes are lowly expressed....
متن کاملAlternative cleavage and polyadenylation during colorectal cancer development.
PURPOSE Alternative cleavage and polyadenylation (APA) of mRNAs is a phenomenon that alters 3'-untranslated region length leading to altered posttranscriptional regulation of gene expression. Changing APA patterns have been shown to result in misregulation of genes involved in carcinogenesis; therefore, we hypothesized that altered APA contributes to progression of colorectal cancer, and that m...
متن کاملCorrection: PAF Complex Plays Novel Subunit-Specific Roles in Alternative Cleavage and Polyadenylation
There is an error in the designations for equal authorship contributions. The first two authors, Yan Yang and Wencheng Li, should be noted as contributing equally to this work. Copyright: © 2016 Yang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided...
متن کاملTranscription elongation rate has a tissue-specific impact on alternative cleavage and polyadenylation in Drosophila melanogaster.
Alternative polyadenylation (APA) is a mechanism that generates multiple mRNA isoforms with different 3'UTRs and/or coding sequences from a single gene. Here, using 3' region extraction and deep sequencing (3'READS), we have systematically mapped cleavage and polyadenylation sites (PASs) in Drosophila melanogaster, expanding the total repertoire of PASs previously identified for the species, es...
متن کاملPAF Complex Plays Novel Subunit-Specific Roles in Alternative Cleavage and Polyadenylation.
The PAF complex (Paf1C) has been shown to regulate chromatin modifications, gene transcription, and RNA polymerase II (PolII) elongation. Here, we provide the first genome-wide profiles for the distribution of the entire complex in mammalian cells using chromatin immunoprecipitation and high throughput sequencing. We show that Paf1C is recruited not only to promoters and gene bodies, but also t...
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ژورنال
عنوان ژورنال: Nucleic Acids Research
سال: 2019
ISSN: 0305-1048,1362-4962
DOI: 10.1093/nar/gkz461